Onco Focus

Tissue base test that screens 52 oncogenes/tumour suppressor genes for hotspot & RNA fusions with current treatment protocol of multiple cancers.

OncoFocus is multi-biomarker assay that enables the detection of hotpots, SNVs, indels, CNVs, and gene fusions across 52 cancer-relevant genes from DNA and RNA.

Categorized by somatic alteration type 52 genes

Hotspot Genes

  • AKT1
  • ALK
  • AR
  • BRAF
  • CDK4
  • CTNNB1
  • DDR2
  • EGFR
  • ERBB2
  • ERBB3
  • ERBB4
  • ESR1
  • FGFR2
  • FGFR3
  • GNAll
  • GNAQ
  • HRAS
  • IDH1
  • IDH2
  • JAK1
  • JAK2
  • JAK3
  • KIT
  • KRAS
  • MAP2K1
  • MAP2K2
  • MET
  • MTOR
  • NRAS
  • PDGFRA
  • PIK3CA
  • RAF1
  • RET
  • ROS1
  • SMO

Copy Number Variants

  • ALK
  • AR
  • BRAF
  • CCND1
  • CDK4
  • CDK6
  • EGFR
  • ERBB2
  • FGFR1
  • FGFR2
  • FGFR3
  • FGFR4
  • KIT
  • RAS
  • MET
  • MYC
  • MYCN
  • PDGFRA
  • PIK3CA

Fusion Drivers

  • ABL1
  • AKT3
  • ALK
  • AXL
  • BRAF
  • EGFR
  • ERBB2
  • ERG
  • E71/1
  • ETV4
  • EN5
  • FGFR1
  • FGFR2
  • FGFR3
  • MET
  • NTRK1
  • NTRK2
  • NTRK3
  • PDGFRA
  • PPARG
  • RAF1
  • RET
  • ROS1

OncoFocus enables to

  • Simultaneous detection of hundreds of variants across 52 genes relevant to solid tumors.
  • Targets relevant hotspots, SNVs, indels, CNVs, and gene fusions from DNA or RNA in a single test.
  • Enables detection of NTRK1, NTRK2, and NTRK3 gene fusions.
  • Includes solid tumor genes targeted by on-market oncology drugs and published evidence
  • Results from even small samples, such as fine-needle aspirates or as few as 2–3 FFPE slides